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Embryo implantation and development are critically dependent upon the spatial and temporal regulation of angiogenesis and localized vascular permeability. A key mediator of these effects is the endothelial cell mitogen vascular endothelial growth factor (VEGF). VEGF has been shown to promote endometrial vascular permeability, fetal vasculogenesis and placental, fetal and maternal angiogenesis. However,...
Embryo implantation and normal placental growth are critically dependent upon the spatial and temporal regulation of angiogenesis and localized vascular permeability. The mechanism through which this regulation occurs remains to be delineated. Vascular Endothelial Growth Factor (VEGF), is an endothelial cell mitogen which promotes endometrial vascular permeability, fetal vasculogenesis and placental,...
Term trophoblasts are known to both produce and respond to a variety of cytokines in response to infection. However, comparatively little is known about the capacity of first trimester trophoblasts to respond to an infection during the early gestation of the embryo and what role if any, these cells play in coordinating an effective immune response. This study was undertaken to better characterize...
Defensins are a broad spectrum antimicrobial and cytotoxic family of proteins which have been identified in polymorphonucleated neutrophils, macrophages and in cells lining the trachea, lung and small intestine. They are characterized as small (4 kilodaltons) argenine rich, single chain peptides with an invariant motif of 6 cysteine residues. This study was undertaken to determine if tissue specific...
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