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Classic central synaptic transmission by fast neurotransmitters—glutamate, GABA or glycine—involves liberation from vesicles directly opposite postsynaptic receptors at junctions containing both a presynaptic active zone and a postsynaptic specialisation. Such classic transmission is thought to underlie much of the information transfer and processing in the brain. However, there also exist a substantial...
The ability to recall past events is a major determinant of survival strategies in all species and is of paramount importance in determining our uniqueness as individuals. In contrast to memory formation, the information about the molecular mechanisms of memory retrieval is surprisingly scarce and fragmentary. Here we show that pretest inhibition of the specific upstream activator of mitogen-activated...
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