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The T cell receptor (TCR) σ locus lies within the TCR α locus and is excised from the chromosome by Vα-Jα rearrangement. We show here that σ sequences persist in a large fraction of the DNA from mature CD4 + CD8 − αβ + mouse thymocytes. Virtually all σ loci in these cells are rearranged and present in extrachromosomal DNA. In immature αβ lineage thymocytes (CD3 −/lo ...