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It is generally accepted that T lymphocytes play a central role in the initiation and maintenance of allograft rejection. Different CD45 isoforms are expressed by T lymphocytes; these include the glycoprotein 220 isoform (CD45RA) and glycoprotein 180 isoform (CD45RO). Following in vitro mitogenic or alloantigenic activation, the CD45RA T-cell isoform switches to memory CD45RO T-cell isoform. A...
Limiting dilution analysis technique was used to enumerate the circulating precursor frequency of donor and third-party-reactive helper T lymphocytes (HTLpf) in 28 renal allograft recipients before (pre-tx) and at three intervals (T1: 60-90 days, T2: 120-180 days, T3: 360-1620 days) after transplantation (post-tx). Two patterns of responses were identified, in group 1 (n = 12), a five to 31-fold reduction...
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