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Menschen mit einer Opioidabhängigkeit erreichen dank Substitutionstherapie in zunehmendem Maße höhere Lebensalter. Daher und wegen der begleitenden Komorbidität treten vermehrt lebenslimitierende Erkrankungen auf. Aufgabe einer Palliativversorgung ist der Erhalt oder Wiedergewinn von Lebensqualität bei Menschen mit lebenslimitierenden Erkrankungen, auch bei denjenigen mit einer Opioidabhängigkeit...
Effects of the antiarrhythmic and antimyotonic drug mexiletine were studied on two sodium channel mutants causing paramyotonia congenita (R1448H) and an overlap paramyotonic and hyperkalemic paralytic syndrome (M1360V). Channels were expressed in human embryonic kidney cells and studied electrophysiologically, using the whole-cell patch-clamp technique. Compared to the wild-type, channel, both mutants...
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