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Background Infantile haemangioma (IH) may present as a precursor area of pallor prior to the initial proliferative phase, which implies that the early lesion may be hypoxic.
Objectives To examine the effect of hypoxia on the expression and activity of two key molecular markers of IH, glucose transporter‐1 (GLUT1) and indoleamine 2,3‐dioxygenase (IDO).
Methods IH endothelial cells express both haematopoietic...
Aims/hypothesis TNF-related apoptosis-inducing ligand (TRAIL) is implicated in the regulation of diabetes and is reduced in patients with cardiovascular disease. Although TRAIL receptors are widespread, and TRAIL can promote cell proliferation and apoptosis, it is not known how TRAIL might protect against diabetes and atherosclerosis. Methods We examined the development of atherosclerosis and diabetes...
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