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This study was designed to investigate the effect of HOE 140 (a bradykinin β 2 receptor antagonist) and N w -nitro-l-arginine methyl-ester (L-NAME, a nitric oxide synthase inhibitor) on endothelial and β-cell function in induced streptozotocine (Stz) diabetic rats. The decrease in the insulinogenic index after Stz efffect (control 286.03 ± 104.12 and Stz 18.22 ± 10.77∗, ∗P < 0.001...