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Intake of a Western diet (WD), which is high in saturated fat and sugar, is associated with deficits in hippocampal-dependent learning and memory processes as well as with markers of hippocampal pathology. In the present study, rats were trained to asymptote on hippocampal-dependent serial feature negative (FN) and hippocampal-independent simple discrimination problems. Performance was then assessed...
The use of low carbohydrate diets to control body weight has increased in recent years. In humans, one consequence of such a diet is the production of ketone bodies, which are used by the brain and body as fuel when glucose is in short supply. It has been previously demonstrated that chronic intracerebroventricular (ICV) administration of β-hydroxybutyrate (β-HB), one of three ketone bodies, reduces...
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