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In order to improve bone regeneration, in particular in aged and multimorbid patients, the development of new adaptive biomaterials and their characterization in terms of their impact on bone biology is warranted. Glycosaminoglycans (GAGs) such as hyaluronan (HA) are major extracellular matrix (ECM) components in bone and may display osteogenic properties that are potentially useful for biomaterial...
Chemoresistance is a critical feature of advanced ovarian cancer with only 30% of patients surviving longer than 5years. We have previously shown that four kallikrein‐related (KLK) peptidases, KLK4, KLK5, KLK6 and KLK7 (KLK4–7), are implicated in peritoneal invasion and tumour growth, but underlying mechanisms were not identified. We also reported that KLK7 overexpression confers chemoresistance to...
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