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Regulated secretion is a defining feature of neurons and endocrine cells. It produces the precisely timed release of chemical messengers that is crucial for the coordina tion of the complex systems that regulate thought, behavior and body homeostasis. The molecular reactions that underlie regulated secretion are an adaptation of constitutive membrane trafficking. Changes in the structure of the proteins...
We applied nonlinear optimization to convert a cannula into a high-resolution computational-fluorescence microscope. The microscope was used to image fluorescent microspheres, genetically-encoded mouse-brain slices, genetically-encoded and fluorescent-stained C. elegans nematodes (both living and dead animals).
AMPA receptors are thought to be a tetrameric assembly of the subunits GluR1-4. We have examined whether two coexpressed subunits (GluR1/2) combine at random to form channels, or preferentially assemble with a specific stoichiometry and spatial configuration. The subunits carried markers controlling ion permeation and desensitization, and these properties were monitored as a function of relative expression...
Glutamate release at central synapses is transduced into a characteristic fast postsynaptic response by AMPA receptor gating and agonist affinity. The effect of two classes of modulators of AMPA receptor desensitization, the benzothiadiazides (cyclothiazide and IDRA 21) and the benzoylpiperidines (CX516 and CX546), were studied on gating kinetics of recombinant, native AMPA receptors and on synaptic...
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