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Nano-hydroxyapatite particles (Ca10(PO4)6(OH)2, nano-HAp), the main inorganic components of human bone and teeth, has attracted much attentions as a kind of biocompatible carrier to construct dual/multi modal bioimaging probes in recent years. However, the currently developed HAp-based probes still have some shortcomings, such as poor mono-dispersion, potential toxicity and none near-infrared emission,...