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Background/Aims: In patients with cirrhosis, decreased renal water excretion is a common complication. Niravoline (RU51599), a κ-opioid receptor agonist, has been shown to induce an aquaretic response. The aim of this study was to evaluate the aquaretic effect and tolerance of niravoline in patients with cirrhosis.Methods: Biochemical tests and hemodynamic values were determined before and 1, 2, 3...
Background/Aims: Alterations in signal transduction in vascular smooth muscle cells may contribute to vascular hyporeactivity in cirrhosis. Protein kinase C plays a role in vascular cell contraction by modifying contractile proteins and intracellulawr [Ca 2+ ] homeostasis. The aim of this study was to examine the vascular reactivity and expression of protein kinase Cα in aortae from rats...
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