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Sμbp-2 is a novel transcription factor that was first identified through its interaction with the immunoglobulin Sμ region (Mizuta et al., 1993) and has been cloned by virtue of its binding to two 12-O-tetradecanoylphorbol-13-acetate-responsive elements in the Epstein–Barr virus immediate-early BZLF1 promoter (Gulley et al., 1997). In this report, we examined the effect of Sμbp-2 overexpression on...
Previous studies have shown that the ZII element in the BZLF1 promoter (P1) is responsive to TPA and anti-immunoglobulin induction. In this report, we have studied the DNA/protein complexes formed when ZII is used as a binding site. Twelve distinct DNA/protein complexes were seen in mobility shift experiments using Akata cell nuclear extracts and radiolabeled ZII. Eleven of these complexes were also...