Search results for: Antonina Joanna Mazur

Items from 1 to 11 out of 11 results

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Analysis of gelsolin expression pattern in developing chicken embryo reveals high GSN expression level in tissues of neural crest origin

Antonina Joanna Mazur, Gabriela Morosan-Puopolo, Aleksandra Makowiecka, Maria Malicka-Błaszkiewicz, more

Brain Structure and Function > 2016 > 221 > 1 > 515-534

Gelsolin is one of the most intensively studied actin-binding proteins. However, in the literature comprehensive studies of GSN expression during development have not been performed yet in all model organisms. In zebrafish, gelsolin is a dorsalizing factor that modulates bone morphogenetic proteins signaling pathways, whereas knockout of the gelsolin coding gene, GSN is not lethal in murine model...

article

Gelsolin interacts with LamR, hnRNP U, nestin, Arp3 and β-tubulin in human melanoma cells as revealed by immunoprecipitation and mass spectrometry

Antonina Joanna Mazur, Tomasz Radaszkiewicz, Aleksandra Makowiecka, Maria Malicka-Błaszkiewicz, more

European Journal of Cell Biology > 2016 > 95 > 1 > 26-41

Gelsolin, a multifunctional actin binding protein, plays a not yet fully understood role in tumorigenesis. Therefore the goal of this study was to identify additional molecular partners of gelsolin in human melanoma cells, separately in the cytoplasmic compartment and cell nuclei. For this purpose we performed immunoprecipitation experiments based on a modified protocol followed by mass spectrometry...

article

Active invadopodia of mesenchymally migrating cancer cells contain both β and γ cytoplasmic actin isoforms

Aleksandra Simiczyjew, Antonina Joanna Mazur, Christophe Ampe, Maria Malicka-Błaszkiewicz, more

Experimental Cell Research > 2015 > 339 > 2 > 206-219

Invadopodia are actin-rich protrusions formed by mesenchymally migrating cancer cells. They are mainly composed of actin, actin-associated proteins, integrins and proteins of signaling machineries. These protrusions display focalized proteolytic activity towards the extracellular matrix. It is well known that polymerized (F-)actin is present in these structures, but the nature of the actin isoform...

article

Thymosin beta4 inhibits ADF/cofilin stimulated F‐actin cycling and hela cell migration: Reversal by active Arp2/3 complex

Abdulatif Al Haj, Antonina Joanna Mazur, Sabine Buchmeier, Christine App, more

Cytoskeleton > 71 > 2 > 95 - 107

F‐actin treadmilling plays a key part in cell locomotion. Because immunofluorescence showed colocalisation of thymosin beta4 (Tβ4) with cofilin‐1 and Arp2/3 complex in lamellipodia, we analyzed combinations of these proteins on F‐actin‐adenosine triphosphate (ATP)‐hydrolysis, which provides a measure of actin treadmilling. Actin depolymerising factor (ADF)/cofilin stimulated treadmilling, while Tβ4...

article

Effect of overexpression of β- and γ-actin isoforms on actin cytoskeleton organization and migration of human colon cancer cells

Aleksandra Simiczyjew, Antonina Joanna Mazur, Agnieszka Popow-Woźniak, Maria Malicka-Błaszkiewicz, more

Histochemistry and Cell Biology > 2014 > 142 > 3 > 307-322

Actins are eukaryotic proteins, which are involved in diverse cellular functions including muscle contraction, cell motility, adhesion and maintenance of cell shape. Cytoplasmic actin isoforms β and γ are ubiquitously expressed and essential for cell functioning. However, their unique contributions are not very well understood. The aim of this study was to determine the effect of β- and γ-actin overexpression...

article

Gelsolin affects the migratory ability of human colon adenocarcinoma and melanoma cells

Monika Litwin, Dorota Nowak, Antonina Joanna Mazur, Dagmara Baczyńska, more

Life Sciences > 2012 > 90 > 21-22 > 851-861

Formation of different protrusive structures by migrating cells is driven by actin polymerization at the plasma membrane region. Gelsolin is an actin binding protein controlling the length of actin filaments by its severing and capping activity. The main goal of this study was to determine the effect of gelsolin expression on the migration of human colon adenocarcinoma LS180 and melanoma A375 cells...

article

Functional characterization of the human α-cardiac actin mutations Y166C and M305L involved in hypertrophic cardiomyopathy

Mirco Müller, Antonina Joanna Mazur, Elmar Behrmann, Ralph P. Diensthuber, more

Cellular and Molecular Life Sciences > 2012 > 69 > 20 > 3457-3479

Inherited cardiomyopathies are caused by point mutations in sarcomeric gene products, including α-cardiac muscle actin (ACTC1). We examined the biochemical and cell biological properties of the α-cardiac actin mutations Y166C and M305L identified in hypertrophic cardiomyopathy (HCM). Untagged wild-type (WT) cardiac actin, and the Y166C and M305L mutants were expressed by the baculovirus/Sf9-cell system...

article

Cofilin overexpression affects actin cytoskeleton organization and migration of human colon adenocarcinoma cells

Agnieszka Popow-Woźniak, Antonina Joanna Mazur, Hans Georg Mannherz, Maria Malicka-Błaszkiewicz, more

Histochemistry and Cell Biology > 2012 > 138 > 5 > 725-736

The dynamic reorganization of actin cytoskeleton is regulated by a large number of actin-binding proteins. Among them, the interaction of ADF/cofilin with monomeric and filamentous actin is very important, since it severs actin filaments. It also positively influences actin treadmilling. The activity of ADF/cofilin is reversibly regulated by phosphorylation and dephosphorylation at Ser-3, with the...

article

Repolymerization of actin from actin:thymosin β4 complex induced by diaphanous related formins and gelsolin

Hans Georg Mannherz, Antonina Joanna Mazur, Brigitte Jockusch

Annals of the New York Academy of Sciences > 1194 > 1 > 36 - 43

The β‐thymosins are peptides of about 5 kDa molecular mass. Thymosin β4 (Tβ4) is the most ubiquitous member of this family and composed of 43 residues. Initially the β‐thymosins were supposed to be specifically produced and released by the thymic gland and to possess hormonal activities modulating the immune response. However, it was later noticed that β‐thymosins are present in the cytoplasm of almost...

article

Modulation of actin filament dynamics by actin-binding proteins residing in lamellipodia

Antonina Joanna Mazur, Dagmar Gremm, Temuujin Dansranjavin, Monika Litwin, more

European Journal of Cell Biology > 2010 > 89 > 5 > 402-413

Lamellipodial extension depends essentially on the polymerisation cycle of actin. In this cellular compartment the rate and extent of actin polymerisation is tightly regulated by a large number of actin-binding proteins. The main regulators comprise proteins of the actin-depolymerising factor (ADF)/cofilin family, which stimulate actin cycling, but there are also minor constituents like gelsolin and...

article

Methotrexate induces apoptosis in CaSki and NRK cells and influences the organization of their actin cytoskeleton

Antonina Joanna Mazur, Dorota Nowak, Hans Georg Mannherz, Maria Malicka-Błaszkiewicz

European Journal of Pharmacology > 2009 > 613 > 1-3 > 24-33

Methotrexate is a widely used drug in treatments of various types of malignancies and in the therapy of rheumatoid arthritis. The goal of our study was to look at the effect of this dihydrofolate reductase inhibitor on the actin cytoskeleton, since actin plays an important role in cancer transformation and metastasis. For this reason we compared results obtained from experiments on CaSki (human uterine...

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