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The formation of antibody and non-specific immunoglobulin under the influence of T-dependent (TD) and type 2 T-independent (TI-2) antigens in mice of two congenic strains CBA (Lyb5-, Lyb5+) and CBA/N (Lyb5-) was studied. TD antigens induced in mice of both strains not only the appearance of antibody-forming cells (AFC), but also a great increase in the number of cells producing non-specific immunoglobulins...
Introduction: T-dependent (DT) and T-independent (TI) antigens induce the polyclonal activation of B cells and nonspecific Ig formation. Mechanism of polyclonal activation under the influence of TI-antigens of type 2 (TI-2) is unclear. In mice anti-TI-2 antibodies are produced by Lyb5+ B cells. The present study was done to determine which of B cell subpopulations is responsible for the nonspecific...
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