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The antiviral activities of interferon (IFN) and neutralizing antibody act synergistically or additively to inhibit picornavirus production. We investigated this difference by comparing the IFN sensitivities of monoclonal antibody resistant (MAR) mutants of Sabin (Sa) and Mahoney (Ma) strains of poliovirus type 1 (PV-1) in the presence of antigen site specific monoclonal antibodies. The antiviral...
Enviradone (EvirD, (E)-1-[(1-methylethyl) sulfonyl]-6-(1-phenyl-1-propenyl)-1H-benzimidazole-2-amine) and Enviroxime (EvirX, 2-amino-1-(isopropyl-sulfonyl)-6-benzimidazole phenyl ketone oxime) inhibited enterovirus 70 (EV70) and coxsackievirus A24 variant (CA24v) infection of conjunctival and laryngeal cells. On average, the continuous presence of 1-3 μg of EvirD or EvirX/ml in cell cultures acutely...
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