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Hormone replacement therapy reverses the decline in stroke volume evident in postmenopausal women. Whether this effect is related to changes in blood volume or to a direct myocardial effect is unknown. Accordingly, we examined individual hormone replacement components, 17β-estradiol (E, an estrogen) and medroxyprogesterone acetate (P, a progestin), for their effect on cardiac function by 2-dimensional...
OBJECTIVES: PRL receptors have been identified on mammalian granulosa cells. We sought to determine if prolactin has a direct effect on FSH receptor binding and P production in cultured granulosa cells. METHODS: Immature granulosa cells obtained from prepubertal pigs were cultured for up to 4 days on laminin in a serum-free medium supplemented with porcine (p)FSH (10 ng/mL), LDL cholesterol, insulin,...
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