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Parvalbumin (PARV) is a Ca2+-binding protein that may offer resistance to cell death as it primarily functions to maintain Ca2+ homeostasis. The purpose of this study was to investigate whether PARV expressing retinal ganglion cells (RGCs) would be more resistant to cell death than RGCs that do not express PARV. RGCs in Sprague–Dawley rats were retrogradely labeled with Fluorogold (FG). After 2–28...
Using a genetic screen in yeast we found that Mycobacterium tuberculosis PE‐PGRS62 was capable of disrupting yeast vacuolar protein sorting, suggesting effects on endosomal trafficking. To study the impact of PE‐PGRS62 on macrophage function, we infected murine macrophages with Mycobacterium smegmatis expressing PE‐PGRS62. Infected cells displayed phagosome maturation arrest. Phagosomes acquired Rab5,...
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