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We studied the general safety, biodistribution and persistence of a naked DNA plasmid in a rat model using intramuscular, intradermal and intravenous routes of administration. Clinical signs were followed up throughout the study and at the necropsy. Tissue samples were collected at the necropsy at 2, 14 and 28 days after injection of 200μg of plasmid DNA and analysed with validated quantitative polymerase...