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Metalloenzymes rank prominently among the potential targets for chelators used therapeutically to alleviate the tissue iron overload that occurs in chronically transfused patients. Non-heme enzymes providing more than one coordination site at their metal center can be expected to be particularly susceptible. The protein hydroxylases figure prominently among this group. We have studied the effect...
S phase entry, i.e. start of DNA replication, is a crucial step in proliferation. Inhibition of S phase entry correlates with inhibition of hypusine formation, an event affecting only the eukaryotic initiation factor 5A (eIF-5A). Its hypusine-containing sequence was postulated to authorize polysomal utilization of specific transcripts for proteins necessary to enable DNA replication. Using mimosine...
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