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Alterations in autonomic nervous system activity (ANSA) participate in arrhythmogenesis but little information exists on the time course of such effects. To address the hypothesis that a window of opportunity exists during which preventive interventions could be employed, we examined the changes in heart rate (HR) and HR variability indices (HRVi), which reflect ANSA, prior to the onset of spontaneous...
Experimental and clinical observations support a role for sympathetic (SA) and parasympathetic (PA) activities in the genesis of ventricular tachyarrhythmias but studies in human patients (pts) have been inconsistent. We used heart rate (HR) variability (HRV) analysis in the frequency domain (FD) to address the hypothesis that short-term changes in SA and PA precede the onset of spontaneous sustained...
Translation of hepatitis C virus (HCV) RNA is directed by an internal ribosome entry site (IRES) which is located within conserved nucleotide sequences at the 5 end of HCV RNA. Antisense oligonucleotides complementary to sequences thought to be important for IRES function were evaluated for inhibition of HCV gene expression in a transformed hepatocyte cell line containing integrated genomic DNA...
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