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The Cosmetics Europe (formerly COLIPA) Genotoxicity Task Force has driven and funded three projects to help address the high rate of misleading positives in in vitro genotoxicity tests:The completed “False Positives” project optimized current mammalian cell assays and showed that the predictive capacity of the in vitro micronucleus assay was improved dramatically by selecting more relevant cells and...
We examined the possible genotoxicity of the recently isolated or developed anti-asthmatic and anti-inflammatory substances Apocynin (CAS 498-02-2) and Acetosyringenin (CAS 2478-38-8) using short term test systems. Apocynin is a constituent of Picrorhiza kurroa, a plant from the Himalaya region. Acetosyringenin is its methoxylated synthetic derivative.The test systems used were the Salmonella typhimurium...
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