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Extracellular matrix (ECM) molecules in the central nervous system form highly organized ECM structures around cell somata, axon initial segments, and synapses and play prominent roles in early development by guiding cell migration, neurite outgrowth and synaptogenesis, and by regulating closure of the critical period of development, synaptic plasticity and stability, cognitive flexibility, and axonal...
We characterized the neuronal two-domain (95kD-α 1 2.1) form of the α 1 2.1 subunit of the voltage-gated calcium channels using genetic and molecular analysis. The 95kD-α 1 2.1 is absent in neuronal preparations from CACNA1A null mouse demonstrating that α 1 2.1 and 95kD-α 1 2.1 arise from the same gene. A recombinant two-domain form (α 1AI ...
T-type Ca2+ currents have been proposed to be involved in the genesis of spike-and-wave discharges, a sign of absence seizures, but direct evidence in vivo to support this hypothesis has been lacking. To address this question, we generated a null mutation of the α1G subunit of T-type Ca2+ channels. The thalamocortical relay neurons of the α1G-deficient mice lacked the burst mode firing of action potentials,...
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