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The pleiotropic functions of tumor necrosis factor-alpha (TNFα) have brought considerable attention in the past decade to its physiological and pathological roles in inflammatory and autoimmune diseases. However, little is known about how the production of TNFα is regulated at the transcriptional and translational levels in immune cells such as T and B lymphocytes. Our previous study demonstrated...
We recently cloned a new mast cell (MC) restricted, Ras guanine nucleotide releasing protein (designated mRasGRP4) from IL-3-developed, mouse bone marrow-derived MCs that can activate varied members of the Ras superfamily of small GTP-binding proteins. We now describe the rat ortholog of this MC-specific guanine exchange factor. Using the mRasGRP4 gene and transcript in a homology-based cloning approach,...
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