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In order to develop cost-effective immunomodulator, the recombinant Pichia pastoris were firstly constructed to co-express porcine IL-2/4/6 genes, and then fermented to feed 45-days Tibetan piglets at different doses to evaluate its effects on immunity of piglets to PRRS vaccination, which simultaneously received intramuscular injection of inactivated PRRS vaccine. The results were found that the...