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In this work, the potential of targeting griseofulvin (GF) into the skin by topical application was evaluated by in-vitro studies. Griseofulvin loaded lipid nanoparticles (GF-LN) were prepared using high pressure homogenization method without any penetration enhancer or solubilizing solvent. The formulations were freeze dried to increase stability of the lipid nanoparticles (LN). The optimum formulation...