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Osteonecrosis of the femoral head (ONFH) is a disabling disease affecting young adults, which usually leads to the destruction of the hip joint. It is mainly due to an inadequate blood supply that causes the death of osteocytes and bone marrow cells. Joint salvaging procedures are numerous but relatively inefficient, justifying the need for new therapeutic strategies. In this regard, the recently...
L’ostéonécrose de la tête fémorale (ONTF) est une maladie invalidante de l’adulte jeune, menant généralement à la destruction de l’articulation de la hanche. Elle est principalement due à un apport sanguin insuffisant qui entraîne la mort des ostéocytes et des cellules de la moelle osseuse. Les méthodes de réparation osseuse sont nombreuses, mais relativement inefficaces, ce qui justifie la nécessité...
Distal control of the whey acidic protein (WAP) locus was studied using a transgenic approach. A series of pig genomic fragments encompassing increasing DNA lengths upstream of the mammary specific whey acidic protein (WAP) gene transcription start point (tsp) and 5 kb downstream were used for microinjection in mouse fertilized eggs. Our data pointed out three regions as potent regulators for WAP...
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