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Depletion of intracellular Ca2+ stores in mammalian cells results in Ca2+ entry across the plasma membrane mediated primarily by Ca2+ release-activated Ca2+ (CRAC) channels. Ca2+ influx through these channels is required for the maintenance of homeostasis and Ca2+ signaling in most cell types. One of the main features of native CRAC channels is fast Ca2+-dependent inactivation (FCDI), where Ca2+ entering...