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Combined inhibition of complement and CD14 is known to attenuate bacterial‐induced inflammation, but the dependency of the bacterial load on this effect is unknown. Thus, we investigated whether the effect of such combined inhibition on Escherichia coli‐ and Staphylococcus aureus‐induced inflammation was preserved during increasing bacterial concentrations. Human whole blood was preincubated with...
Cholesterol crystals are known to be a hallmark of atherosclerosis with recent studies demonstrating deposition of these crystals in early fatty streak formation as well as penetrating the intima following plaque rupture. Inflammation has also become a central focus in atheroma development and endothelial cell activation is recognized as necessary for the recruitment of inflammatory cells to the plaque...
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