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Reversed Mitochondrial Dysfunction
Fullerenol nanoparticles are both stable and effective in protecting the degenerating retina. In article number 2205998, Yu Gong, Zhanjun Gu, Haiwei Xu, and co‐workers propose the potential utility of fullerenols for safeguarding the mitochondrial genome to maintain electron transport chain function and simultaneously reversing the abnormal nuclear DNA expression...
Poor therapeutic outcomes of antioxidants in ophthalmologic clinical applications, including glutathione during photoreceptor degeneration in retinitis pigmentosa (RP), are caused by limited anti‐oxidative capacity. In this study, fullerenols are synthesized and proven to be highly efficient in vitro radical scavengers. Fullerenol‐based intravitreal injections significantly improve the flash electroretinogram...
Lead‐based perovskite nanoparticles (Pb‐PNPs) with superior optoelectronic properties are promising alternatives for the next generation of photovoltaics materials. This raises a great concern about their potential exposure toxicity in biological systems. However, little is known about their adverse effects on the gastrointestinal tract system so far. Here, the aim is to investigate the biodistribution,...
A key characteristic of radiation‐induced oral mucositis (RIOM) is oxidative stress mediated by the “reactive oxygen species (ROS) storm” generated from water radiolysis, resulting in severe pathological lesions, accompanied by a disturbance of oral microbiota. Therefore, a sprayable in situ hydrogel loaded with “free radical sponge” fullerenols (FOH) is developed as antioxidant agent for RIOM radioprotection...
Radiation dermatitis is a common but torturous side effect during radiotherapy, which greatly decreases the life quality of patients and potentially results in detrimental cessation of tumor treatment. Fullerenol, known as “free radical sponge,” is a great choice for skin radioprotection because of its broad‐spectrum free radical scavenging performance, good chemical stability, and biosafety. In this...
In the field of nano‐ and microscale science and technology, Small has become one of the worldwide leading journals since its initiation 15 years ago. Among all the topics covered in Small, “nanosafety” has received growing interest over the years, which accounts for a large proportion of the total publications of Small. Herein, inspired by its coming Special Issue “Rethinking Nanosafety,” a general...
The exploration of an old drug for new biomedical applications has an absolute predominance in shortening the clinical conversion time of drugs for clinical application. In this work, carbon nanoparticles suspension injection (CNSI), the first clinically approved carbon nanoparticles in China, is explored as a new nano‐radioprotective agent for potent intestinal radioprotection. CNSI shows powerful...
Carbon monoxide (CO) therapy has emerged as a hot topic under exploration in the field of gas therapy as it shows the promise of treating various diseases. Due to the gaseous property and the high affinity for human hemoglobin, the main challenges of administrating medicinal CO are the lack of target selectivity as well as the toxic profile at relatively high concentrations. Although abundant CO releasing...
The rising dangers of bacterial infections have created an urgent need for the development of a new generation of antibacterial nanoagents and therapeutics. A new near‐infrared 808 nm laser‐mediated nitric oxide (NO)‐releasing nanovehicle (MoS2‐BNN6) is reported through the simple assembly of α‐cyclodextrin‐modified MoS2 nanosheets with a heat‐sensitive NO donor N,N′‐di‐sec‐butyl‐N,N′‐dinitroso‐1,4‐phenylenediamine...
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