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The aim of this study was to determine whether tachykinin receptors might be involved in the mediation of the atropine- and capsaicin-sensitive third phase of a triphasic contractile response to vagal nerve stimulation of the guinea-pig isolated oesophagus. The third phase was inhibited 23.3 ± 1.7% (P< 0.001, n = 5) and 30.8 ± 9.0% (P< 0.05, n = 5) by the NK 3 receptor antagonist, SR...