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Quantitative in situ hybridization histochemistry was used to compare the effects of AMPH administration on mRNAs coding forzif/268, a member of the zinc finger family of immediate early genes, and the opioid peptides, preprodynorphin (PPD) and preproenkephalin (PPE), in rat striatum after 3 dosing schedules: (1) acute; (2) once a day for 5 days, and (3) once a day for 5 days followed 10 days later...
Recent evidence has demonstrated that N-methyl-d-aspartic acid (NMDA) and non-NMDA, excitatory amino acid (EAA) receptor antagonists block the motor stimulating, neurotoxic, and rewarding actions of cocaine and the amphetamines. The participants in this symposium discussed evidence that (i) the initiation of stimulant-induced behavioral sensitization involves NMDA receptor stimulation in the ventral...
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