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Exposure to ambient particulate matter (PM) has been associated with adverse cardiopulmonary effects where inflammation seems to play an important role. Cellular release of inflammatory mediators is therefore commonly measured in in vitro studies of PM-induced effects. However, adsorption of such mediators to PM may interfere with these measurements and thereby possibly also influence the conclusions...
The pro-inflammatory cytokines IL-1β, TNF-α and IL-6 are of great importance in the development of silica-induced lung damage and repair. In this study we investigated the role of IL-1β, TNF-α and COX2 in silica-induced regulation of IL-6 release and pneumocyte loss in various mono- and co-cultures of monocytes, pneumocytes and endothelial cells.All co-cultures with monocytes, and especially cultures...
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