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We examined the internal mobility of the estrogen receptor DNA-binding domain (ER DBD) using NMR 15 N relaxation measurements and compared it to that of the glucocorticoid receptor DNA-binding domain (GR DBD). The studied protein fragments consist of residues Arg183-His267 of the human ER and residues Lys438-Gln520 of the rat GR. The 15 N longitudinal (R 1 ) and transverse...