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Saccharomyces cerevisiae Saw1 is an essential gene in single-strand annealing – the DNA repair pathway that repairs double-strand breaks when they occur between homologous repeats. Saw1 interacts with the structure-specific nuclease Rad1-Rad10 and this results in the recruitment of this nuclease to 3′ non-homologous DNA tailed recombination intermediates. Saw1 is unstable in the absence of the Rad1-Rad10...