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(1) Preincubation of SKOV3 human ovarian carcinoma cells with a non-toxic dose of Geldanamycin resulted in exacerbation of hyperthermia-induced cytotoxicity and re-distribution of dying cells toward necrosis. (2) Exposure of primary human ovarian carcinoma cells to mild hyperthermia (42°C for 2h) led, after a recovery period of 16h, to several-fold increase in the levels of Hsp90 and ErbB2, to a moderate...
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