The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Introduction: Data indicates that TGF-betas may play an important role in craniosynostosis. In a murine organ culture model, we previously demonstrated that blocking TGF-beta signaling leads to pathologic suture patency. In this study, we investigated both the osteogenic properties of TGF-beta1 and determined whether adenoviral overexpression of TGF-beta1 in a normally patent sagittal (SAG) suture...
Introduction: Guided tissue regeneration (GTR) utilizes barrier materials to create environments that favor tissue regeneration. In the current study, we applied the principle of GTR to our rat mandibular distraction osteogenesis (DO) model in an attempt to enhance bone regeneration.Methods: Osteoconductive Gore Resolut XT membranes (a co-polymer of polylactic acid and polyglycolic acid) were used...
Introduction: Cleft palate is a common disorder that occurs when there is failure of the palatal shelves to fuse during normal development. The genes mediating normal palatal fusion are largely unknown.Methods: We harvested mRNA and performed microarray (~40,000 element) analysis of mice palatal shelves at timepoints before, during, and after palatal fusion (E13.5, E14.5, and E15.5). IHC was performed...
Introduction: Understanding cranial suture developmental biology is important in elucidating the pathogenesis of craniosynostosis. Although recent studies in cranial suture biology have focused on growth factors and transcription factors, few have investigated adhesion molecules and the role they may play in cell migration and bone formation.Methods: RNA were extracted from posterior frontal (PF)...