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In an attempt to identify the cardiac-specific genes regulated by the transcription factor GATA-4, we have identified a putative GATA-binding site located within the 5 flanking sequence of the human cardiac α-myosin heavy-chain-encoding gene. The 23-bp sequence surrounding the core GATA-binding site is conserved across species. The core motif and flanking sequences of this GATA-binding site are...