Search results for: Hemlata Patil

Items from 1 to 14 out of 14 results

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Coupling 3D printing with hot-melt extrusion to produce controlled-release tablets

Jiaxiang Zhang, Xin Feng, Hemlata Patil, Roshan V. Tiwari, more

International Journal of Pharmaceutics > 2017 > 519 > 1-2 > 186-197

The main objective of this work was to explore the potential of coupling fused deposition modeling in three-dimensional (3D) printing with hot-melt extrusion (HME) technology to facilitate additive manufacturing, in order to fabricate tablets with enhanced extended release properties. Acetaminophen was used as the model drug and different grades and ratios of polymers were used to formulate tablets...

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The effects of polymer carrier, hot melt extrusion process and downstream processing parameters on the moisture sorption properties of amorphous solid dispersions

Xin Feng, Anh Vo, Hemlata Patil, Roshan V. Tiwari, more

Journal of Pharmacy and Pharmacology > 68 > 5 > 692 - 704

ObjectiveThe aim of this study was to evaluate the effect of polymer carrier, hot melt extrusion and downstream processing parameters on the water uptake properties of amorphous solid dispersions. MethodsThree polymers and a model drug were used to prepare amorphous solid dispersions utilizing the hot melt extrusion technology. The sorption–desorption isotherms of solid dispersions and their physical...

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Recent advancements in mucoadhesive floating drug delivery systems: A mini-review

Hemlata Patil, Roshan V. Tiwari, Michael A. Repka

Journal of Drug Delivery Science and Technology > 2016 > 31 > Complete > 65-71

Over the past few decades, extensive research has been carried out to develop a gastroretentive dosage form (GRDF). This type of dosage form can improve the delivery and performance of drugs that are locally active in the stomach because the GRDF allows the drug to remain in the stomach for a sufficient time interval. Different approaches have been used to develop efficient GRDFs such as low density...

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Conjugation of Hot-Melt Extrusion with High-Pressure Homogenization: a Novel Method of Continuously Preparing Nanocrystal Solid Dispersions

Xingyou Ye, Hemlata Patil, Xin Feng, Roshan V. Tiwari, more

AAPS PharmSciTech > 2016 > 17 > 1 > 78-88

Over the past few decades, nanocrystal formulations have evolved as promising drug delivery systems owing to their ability to enhance the bioavailability and maintain the stability of poorly water-soluble drugs. However, conventional methods of preparing nanocrystal formulations, such as spray drying and freeze drying, have some drawbacks including high cost, time and energy inefficiency, traces of...

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Hot-Melt Extrusion: from Theory to Application in Pharmaceutical Formulation

Hemlata Patil, Roshan V. Tiwari, Michael A. Repka

AAPS PharmSciTech > 2016 > 17 > 1 > 20-42

Hot-melt extrusion (HME) is a promising technology for the production of new chemical entities in the developmental pipeline and for improving products already on the market. In drug discovery and development, industry estimates that more than 50% of active pharmaceutical ingredients currently used belong to the biopharmaceutical classification system II (BCS class II), which are characterized as...

article

Thermoreversible nanoethosomal gel for the intranasal delivery of Eletriptan hydrobromide

Santosh Shelke, Sadhana Shahi, Kiran Jadhav, Dinesh Dhamecha, more

Journal of Materials Science: Materials in Medicine > 2016 > 27 > 6 > 1-13

The objective of the current study was to formulate and characterize thermoreversible gel of Eletriptan Hydrobromide for brain targeting via the intranasal route. Ethosomes were prepared by 3² factorial design with two independent variables (concentration of soya lecithin and ethanol) and two response variables [percent entrapment efficiency and vesicle size (nm)] using ethanol injection method. Formulated...

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Energy-Decisive and Upgrade Cooperative Spectrum Sensing in Cognitive Radio Networks

Alpa Chaudhary, Manoj Dongre, Hemlata Patil

Procedia Computer Science > 2016 > 79 > C > 683-691

In recent year energy efficiency and sensing time are become disparaging corner for cognitive radio (CR) networks, as network become deliberately energy-onerous. Cognitive radio intensify the pliability of personal services through language that illustrate knowledge of radio protocol, software module, proliferations, networks, user needs, and application scenario in a way that supports automated reasoning...

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Formulation and development of pH-independent/dependent sustained release matrix tablets of ondansetron HCl by a continuous twin-screw melt granulation process

Hemlata Patil, Roshan V. Tiwari, Sampada B. Upadhye, Ronald S. Vladyka, more

International Journal of Pharmaceutics > 2015 > 496 > 1 > 33-41

The objective of the present study was to develop pH-independent/dependent sustained release (SR) tablets of ondansetron HCl dihydrate (OND), a selective 5-HT₃ receptor antagonist that is used for prevention of nausea and vomiting caused by chemotherapy, radiotherapy and postoperative treatment. The challenge with the OND API is its pH-dependent solubility and relatively short elimination half-life...

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Development of an Ointment Formulation Using Hot-Melt Extrusion Technology

Ajinkya M. Bhagurkar, Muralikrishnan Angamuthu, Hemlata Patil, Roshan V. Tiwari, more

AAPS PharmSciTech > 2016 > 17 > 1 > 158-166

Ointments are generally prepared either by fusion or by levigation methods. The current study proposes the use of hot-melt extrusion (HME) processing for the preparation of a polyethylene glycol base ointment. Lidocaine was used as a model drug. A modified screw design was used in this process, and parameters such as feeding rate, barrel temperature, and screw speed were optimized to obtain a uniform...

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Rat Palatability Study for Taste Assessment of Caffeine Citrate Formulation Prepared via Hot-Melt Extrusion Technology

Roshan V. Tiwari, Ashley N. Polk, Hemlata Patil, Xingyou Ye, more

AAPS PharmSciTech > 2017 > 18 > 2 > 341-348

Developing a pediatric oral formulation with an age-appropriate dosage form and taste masking of naturally bitter active pharmaceutical ingredients (APIs) are key challenges for formulation scientists. Several techniques are used for taste masking of bitter APIs to improve formulation palatability; however, not all the techniques are applicable to pediatric dosage forms because of the limitations...

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Continuous Production of Fenofibrate Solid Lipid Nanoparticles by Hot-Melt Extrusion Technology: a Systematic Study Based on a Quality by Design Approach

Hemlata Patil, Xin Feng, Xingyou Ye, Soumyajit Majumdar, more

The AAPS Journal > 2015 > 17 > 1 > 194-205

This contribution describes a continuous process for the production of solid lipid nanoparticles (SLN) as drug-carrier systems via hot-melt extrusion (HME). Presently, HME technology has not been used for the manufacturing of SLN. Generally, SLN are prepared as a batch process, which is time consuming and may result in variability of end-product quality attributes. In this study, using Quality by...

article

Continuous manufacturing of solid lipid nanoparticles by hot melt extrusion

Hemlata Patil, Vijay Kulkarni, Soumyajit Majumdar, Michael A. Repka

International Journal of Pharmaceutics > 2014 > 471 > 1-2 > 153-156

Solid lipid nanoparticles (SLN) can either be produced by hot homogenization of melted lipids at higher temperatures or by a cold homogenization process. This paper proposes and demonstrates the formulation of SLN for pharmaceutical applications by combining two processes: hot melt extrusion (HME) technology for melt-emulsification and high-pressure homogenization (HPH) for size reduction. This work...

article

A solution-processable electron acceptor based on diketopyrrolopyrrole and naphthalenediimide motifs for organic solar cells

Hemlata Patil, Akhil Gupta, Ante Bilic, Sidhanath V. Bhosale, more

Tetrahedron Letters > 2014 > 55 > 32 > 4430-4432

A novel, solution-processable small molecular electron acceptor (HP1) based on diketopyrrolopyrrole and naphthalenediimide fragments was designed and synthesized via a Stille coupling reaction, characterized by spectroscopic means, and exhibited excellent solubility and thermal stability. HP1 exerted strong and very broad absorption tailing into the near infra-red region, with appropriate energy levels...

article

Donor–Acceptor–Donor Modular Small Organic Molecules Based on the Naphthalene Diimide Acceptor Unit for Solution-Processable Photovoltaic Devices

Hemlata Patil, Akhil Gupta, Ante Bilic, Sam Leslie Jackson, more

Journal of Electronic Materials > 2014 > 43 > 9 > 3243-3254

Two novel solution-processable small organic molecules, 4,9-bis(4-(diphenylamino)phenyl)-2,7-dioctylbenzo[3,8]phenanthroline-1,3,6,8(2H,7H)-tetraone (S6) and 4,9-bis(benzo[b]thiophen-2-yl)-2,7-dioctylbenzo[3,8]phenanthroline-1,3,6,8 (2H,7H)-tetraone (S7), have been successfully designed, synthesized, characterized, and applied in solution-processable photovoltaic devices. S6 and S7 contain a common...

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