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The GAIIG sequence, common to the amyloid beta peptide (residues 29–33) and to the HIV‐1 gp120 (residues 24–28 in a typical V3 loop), self‐assembles into amyloid fibrils, as suggested by theory and the experiments presented here. The longer YATGAIIGNII sequence from the V3 loop also self‐assembles into amyloid fibrils, of which the first three and the last two residues are outside the amyloid GAIIG...
With the goal in mind of developing new and much-improved drug anchoring regimes, we strategically modified the organic linker of IRMOF-16 by introducing hydroxyl groups. In this way, we improved the interaction energy of the anticancer drug gemcitabine with the nano-carrier by 40% compared to the unmodified one. Moreover, our simulations revealed high drug loading capacity in the OH-functionalized-IRMOF-16...
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