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This paper describes the use of Spin Centrifugation–Dialysis (SCD) for small-scale concentration/purification of siRNA–lipid complexes designed for use as therapeutic agents for gene silencing. SCD consists of a two-step method for concentration, filtration and buffer exchange of Lipid Nanoparticles (LNP) to provide a homogeneous preparation suitable for injection. Here, we compare SCD with the more...