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With the explosion of protein sequences generated in the postgenomic era, there is a need for the development of computational methods to characterize and classify them as an alternative to the experimental methods that are expensive and time consuming. Although the amino acid chains that constitute proteins are originally symbolic chains they can be converted into numerical sequences and processed...
To test the neurotoxic hypothesis of excitatory amino acids, we evaluated the possible contribution to the free acidic amino acid pool of Aspartyl-aminopeptidase activity in the frontal cortex of adult (3 month old) and aged rats (3 groups of animals aged 26, 29 and 33 months). Aspartyl-aminopeptidase activity showed a significant decrease in the oldest rats (29 and 33 months old) whereas the activity...
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