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Skin, an important component of composite tissue allografts is considered to be among the most immunogenic of tissues. The mechanisms of resistance of skin allografts to pharmacological immunosuppression remain unknown. We investigated this problem at the level of antigen presentation by graft dendritic cells (DC) to recipient lymphocytes (L). Cells obtained from lymph draining skin were examined...
Introduction: Langerhans cells constitute together with other skin dendritic cells (DC) a distinct group of potent antigen-presenting cells found in circulation as well as within both lymphoid and non-lymphoid tissues. Although their importance as the most effective cells involved in the initiation of primary T lymphocyte immune responses has been demonstrated, no DC-specific marker has been identified...
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