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Objective
Glutamate‐gated N‐methyl‐d‐aspartate receptors (NMDARs) are instrumental to brain development and functioning. Defects in the GRIN2A gene, encoding the GluN2A subunit of NMDARs, cause slow‐wave sleep (SWS)‐related disorders of the epilepsy‐aphasia spectrum (EAS). The as‐yet poorly understood developmental sequence of early EAS‐related phenotypes, and the role of GluN2A‐containing NMDARs...
Objective
The epilepsy‐aphasia spectrum (EAS) is a heterogeneous group of age‐dependent childhood disorders characterized by sleep‐activated discharges associated with infrequent seizures and language, cognitive, and behavioral deficits. Defects in the GRIN2A gene, encoding a subunit of glutamate‐gated N‐methyl‐d‐aspartate (NMDA) receptors, represent the most important cause of EAS identified so...
Whisker stimulation evokes bursts of activity organized in gamma frequency band oscillations in the corresponding barrel of the neonatal rat barrel cortex, so called early gamma oscillations (EGOs). Here, we show that EGO properties dynamically change during the sensory-evoked response, including (i) a progressive decrease in the EGOs’ dominant frequency, (ii) a decrease in the gamma trough amplitudes,...
Physiological ketosis is a hallmark of metabolism in suckling infants. However, little is known on the impact of physiological ketosis on brain excitability. We addressed this question in suckling rats in vivo. 16-channel extracellular field potential recordings were performed from somatosensory barrel cortex at postnatal days 5–9 non-anaesthetized rat pups. Seizures were induced by the volatile convulsant...
Developing cortex generates endogenous activity that modulates the formation of functional units, but how this activity is altered to support mature function is poorly understood. Using recordings from the visual cortex of preterm human infants and neonatal rats, we report a “bursting” period of visual responsiveness during which the weak retinal output is amplified by endogenous network oscillations,...
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