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The study deals with the diplomatic relations between the Holy See and Fascist Italy over the period of 1922–1929. In the period of the dramatic events in the 1920s, it follows up on the final phase of the so-called Rome question, which was opened after World War I. It describes each of the meetings and analyses the requirements of both sides, which resulted in the signing of Lateran Treaty in February...
Interleukin-2 (IL-2) is a pleiotropic cytokine that regulates immune cell homeostasis and has been used to treat a range of disorders including cancer and autoimmune disease. IL-2 signals via interleukin-2 receptor-β (IL-2Rβ):IL-2Rγ heterodimers on cells expressing high (regulatory T cells, Treg) or low (effector cells) amounts of IL-2Rα (CD25). When complexed with IL-2, certain anti-cytokine antibodies...
IL-2 and IL-15 are structurally relative cytokines that share two receptor subunits, CD132 (γ c chain) and CD122 (β chain). However, the expression pattern and physiological role of IL-2 and IL-15 private receptor α chains CD25 and IL-15Rα, respectively, are strikingly different. CD25, together with CD122 and CD132, forms a trimeric high affinity IL-2 receptor that is expressed and functions...
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