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Adaptor proteins play critical roles in lymphocyte activation by mediating intermolecular interactions and assembling signaling complexes at the activated plasma membrane. Bam32/DAPP1 and the related adaptor proteins TAPP1 and TAPP2 were identified by multiple groups about 5 years ago and considerable progress has been made in elucidating the structure, interaction partners and function of these molecules...
The CDS glycoprotein serves as a coreceptor for T cell receptor (TCR)-mediated recognition of peptides associated to MHC class IIn CD Sa deficiency, MHC class-I restricted cytotoxic T lymphocytes (CTL) are absent and lineage commitment to CDS cells is impairedWe described a pharmacological approach to reduce the amount of CDS surface glycoproteins on human peripheral blood T cellsUsing calyculin A,...
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