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Human cytomegalovirus (HCMV) infection is associated with renal allograft failure. Allograft damage in animal models is accelerated by CMV‐induced T helper 17 (Th17) cell infiltrates. However, the mechanisms whereby CMV promotes Th17 cell‐mediated pathological organ inflammation are uncharacterized. Here we demonstrate that murine CMV (MCMV)‐induced intragraft Th17 cells have a Th1/17 phenotype co‐expressing...
To monitor B cell subsets in peripheral circulation to find a distinctive phenotypic signature of rejection in our cohort.The study population consisted of 211 consecutive first renal allograft recipients who were followed up for 12months post-transplant. One ml of EDTA peripheral venous blood was collected pre- transplant, 1month, 3months, 6months, 12months post-transplant and at the time of graft...
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