Search results for: MaryFran R. Sowers

Items from 1 to 20 out of 22 results

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Intra-thoracic fat, cardiometabolic risk factors, and subclinical cardiovascular disease in healthy, recently menopausal women screened for the Kronos Early Estrogen Prevention Study (KEEPS)

Gary Huang, Dan Wang, Irfan Zeb, Matthew J. Budoff, more

Atherosclerosis > 2012 > 221 > 1 > 198-205

To examine the correlations between intra-hepatic and intra-thoracic (total, epicardial, and pericardial) fat deposition with cardiovascular disease (CVD) risk factors and subclinical atherosclerosis burden in healthy, recently postmenopausal women.Women screened for the Kronos Early Estrogen Prevention Study (mean age 52.9 years) who underwent electron beam or multidetector computed tomography (CT)...

article

Genetic polymorphisms and obesity influence estradiol decline during the menopause

MaryFran R. Sowers, John F. Randolph, Huiyong Zheng, Mary Jannausch, more

Clinical Endocrinology > 74 > 5 > 618 - 623

Objectives Obesity and genetic variation in aromatase and type 1 17‐β hydroxysteroid dehydrogenase (HSD) could influence the E2 trajectory of decline during the menopause transition. Design and participants E2 trajectories during the menopause transition (phenotype) were identified using 5934 data points acquired annually from 681 women in Study of Women’s Health across the Nation (SWAN), a multiethnic...

article

Physical functioning among mid-life women: Associations with trajectory of depressive symptoms

Kristin Tomey, MaryFran R. Sowers, Sioban Harlow, Mary Jannausch, more

Social Science & Medicine > 2010 > 71 > 7 > 1259-1267

During midlife, physical functioning limitations emerge and depressive symptoms are highly prevalent. We examined the relationship between physical functioning and depressive symptoms in the Michigan Study of Women’s Health Across the Nation (SWAN) cohort of mid-life women (n = 377). Seven performance-based physical functioning measures quantifying strength, balance, coordination, flexibility and...

article

Relating smoking, obesity, insulin resistance, and ovarian biomarker changes to the final menstrual period

MaryFran R. Sowers, Daniel McConnell, Matheos Yosef, Mary L. Jannausch, more

Annals of the New York Academy of Sciences > 1204 > 1 > 95 - 103

To determine if smoking, obesity, and insulin resistance mediated age at final menstrual period (FMP), we examined anti‐Müllerian hormone (AMH), inhibin B, and follicle‐stimulating hormone (FSH) as biomarkers of changing follicle status and ovarian aging. We performed a longitudinal data analysis from a cohort of premenopausal women followed to their FMP. Our results found that smokers had an earlier...

article

Sex steroid metabolism polymorphisms and mammographic density in pre- and early perimenopausal women

Carolyn J Crandall, Mary E Sehl, Sybil L Crawford, Ellen B Gold, more

Breast Cancer Research > 2009 > 11 > 4 > 1-15

Introduction We examined the association between mammographic density and single-nucleotide polymorphisms (SNPs) in genes encoding CYP1A1, CYP1B1, aromatase, 17β-HSD, ESR1, and ESR2 in pre- and early perimenopausal white, African-American, Chinese, and Japanese women. Methods The Study of Women's Health Across the Nation is a longitudinal community-based cohort study. We analyzed data from 451 pre-...

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Change in adipocytokines and ghrelin with menopause

MaryFran R. Sowers, Rachel P. Wildman, Peter Mancuso, Aimee D. Eyvazzadeh, more

Maturitas > 2008 > 59 > 2 > 149-157

To determine if ghrelin and adipocytokine (leptin, adiponectin, resistin) levels vary with menopause stage or with estradiol (E2), testosterone (T), follicle-stimulating hormone (FSH) and sex hormone-binding globulin (SHBG) concentrations measured in three stages of the menopause transition.A study of adipocytokines and menopause was nested in a population-based, longitudinal study of Caucasian women...

article

The Association of Bone Mineral Density with Estrogen Receptor Gene Polymorphisms

Gail A. Greendale, Jian Chu, Robert Ferrell, John F. Randolph, more

The American Journal of Medicine > 2006 > 119 > 9 Supplement 1 > S79-S86

The purpose of this investigation was to evaluate single nucleotide polymorphism (SNP) variants of the estrogen receptor genes ESR1 and ESR2 and bone mineral density (BMD) of the lumbar spine (LS-BMD) or total hip (hip BMD) in women of 4 races/ethnicities who were premenopausal or in early perimenopause. The sample consisted of 1,301 participants from the Study of Women’s Health Across the Nation...

article

CYP1A1 and CYP1B1 Polymorphisms and Their Association with Estradiol and Estrogen Metabolites in Women Who Are Premenopausal and Perimenopausal

MaryFran R. Sowers, Angela L. Wilson, Sharon R. Kardia, Jian Chu, more

The American Journal of Medicine > 2006 > 119 > 9 Supplement 1 > S44-S51

The purpose of this study was to relate measured concentrations of estradiol (E ₂ ) and the urinary estrogen metabolites 2-hydroxyestrone (2-OHE1) and 16α-hydroxyestrone (16α-OHE1) to single nucleotide polymorphisms (SNPs) from CYP1A1 and CYP1B1, the primary genes involved in estrogen catabolism. We investigated the association of 4 CYP1A1 SNPs (CYP1A1 rs4646903, CYP1A1 rs1531163, CYP1A1 rs2606345,...

article

Sex Steroid Hormone Pathway Genes and Health-Related Measures in Women of 4 Races/Ethnicities: The Study of Women’s Health Across the Nation (SWAN)

MaryFran R. Sowers, Angela L. Wilson, Carrie A. Karvonen-Gutierrez, Sharon R. Kardia

The American Journal of Medicine > 2006 > 119 > 9 Supplement 1 > S103-S110

We synthesized findings relating health outcomes and genetic variants of the sex steroid hormone pathway in women from the Study of Women’s Health Across the Nation (SWAN) Genetics Study. The SWAN Genetics Study, a component of the longitudinal SWAN study, describes selected genetics characteristics of health-related attributes during the menopausal transition in African American, Caucasian, Chinese,...

article

Cognitive Functioning and Sex Steroid Hormone Gene Polymorphisms in Women at Midlife

Howard M. Kravitz, Peter M. Meyer, Teresa E. Seeman, Gail A. Greendale, more

The American Journal of Medicine > 2006 > 119 > 9 Supplement 1 > S94-S102

Single nucleotide polymorphism (SNP) genotype frequencies were examined to determine whether variation in 6 estrogen-related genes was associated with differences in cognitive functioning in women at midlife. DNA from a multiracial/multiethnic sample of 875 African American, Caucasian, Chinese, and Japanese women aged 45 to 56 years participating in the Study of Women’s Health Across the Nation (SWAN)...

article

Introduction

MaryFran R. Sowers

The American Journal of Medicine > 2006 > 119 > 9 Supplement 1 > S1-S2

article

The Association of Genetic Polymorphisms in Sex Hormone Biosynthesis and Action with Insulin Sensitivity and Diabetes Mellitus in Women at Midlife

Joan C. Lo, Xinhua Zhao, Angelo Scuteri, Sarah Brockwell, more

The American Journal of Medicine > 2006 > 119 > 9 Supplement 1 > S69-S78

We evaluated associations of insulin sensitivity, metabolic syndrome, and diabetes mellitus with single nucleotide polymorphism (SNP) variants from sex hormone biosynthesis and action in women of 4 races/ethnicities. DNA was extracted from transformed cell samples of 1,538 women in the Study of Women’s Health Across the Nation (SWAN). African American, Caucasian, Chinese, and Japanese women in SWAN...

article

Menstrual Cycle Markers of Ovarian Aging and Sex Steroid Hormone Genotypes

MaryFran R. Sowers, Mary L. Jannausch, Daniel S. McConnell, Sharon R. Kardia, more

The American Journal of Medicine > 2006 > 119 > 9 Supplement 1 > S31-S43

We related variation in 4 sex steroid genes to 3 phenotypic indicators of ovarian aging, including no evidence of luteal activity as a marker of anovulatory cycles, shorter or longer menstrual cycle lengths, and the profiles of metabolites of estrogens, progesterone, follicle-stimulating hormone, and luteinizing hormone measured in urine samples collected daily across a menstrual cycle in women aged...

article

Sex Steroid Hormone Polymorphisms, High-Density Lipoprotein Cholesterol, and Apolipoprotein A-1 from the Study of Women’s Health Across the Nation (SWAN)

MaryFran R. Sowers, James P. Symons, Mary L. Jannausch, Jian Chu, more

The American Journal of Medicine > 2006 > 119 > 9 Supplement 1 > S61-S68

We evaluated potential associations between single nucleotide polymorphism (SNP) variants in estrogen receptor (ERα and ERβ) genes, high-density lipoprotein (HDL) cholesterol, and apolipoprotein A-1 (apoA-1) concentrations in women of 4 races/ethnicities. Participants included 1,520 African American, Caucasian, Chinese, and Japanese women from the Study of Women’s Health Across the Nation (SWAN) who...

article

Endogenous Estradiol and Its Association with Estrogen Receptor Gene Polymorphisms

MaryFran R. Sowers, Mary L. Jannausch, Daniel S. McConnell, Sharon R. Kardia, more

The American Journal of Medicine > 2006 > 119 > 9 Supplement 1 > S16-S22

We evaluated potential associations between single nucleotide polymorphism (SNP) variants of the estrogen receptor genes ESR1 and ESR2 and circulating estradiol (E ₂ ) concentrations in women of 4 races/ethnicities. The study population was drawn from participants in the Study of Women’s Health Across the Nation (SWAN). A total of 1,538 African American, Caucasian, Chinese, and Japanese women...

article

Characterizing Variation in Sex Steroid Hormone Pathway Genes in Women of 4 Races/Ethnicities: The Study of Women’s Health Across the Nation (SWAN)

Sharon R. Kardia, Jian Chu, MaryFran R. Sowers

The American Journal of Medicine > 2006 > 119 > 9 Supplement 1 > S3-S15

This report characterizes genotypes and haplotypes in 6 genes (27 single nucleotide polymorphisms [SNPs]) from the Sex Steroid Hormone Genetics Protocol developed though the DNA Repository of the Study of Women’s Health Across the Nation (SWAN) Genetics Study. The SWAN Genetics Study is a component of a longitudinal study describing health-related attributes of the menopausal transition in African...

article

Aromatase Gene (CYP 19) Polymorphisms and Endogenous Androgen Concentrations in a Multiracial/Multiethnic, Multisite Study of Women at Midlife

MaryFran R. Sowers, Angela L. Wilson, Sharon R. Kardia, Jian Chu, more

The American Journal of Medicine > 2006 > 119 > 9 Supplement 1 > S23-S30

A limited number of studies have focused on androgens in women’s health, particularly at the genetic level. We evaluated testosterone and estradiol (E ₂ ) levels among women in relation to 5 single nucleotide polymorphisms (SNPs) of the aromatase (CYP 19) gene, the cytochrome P450 enzyme that converts androgens to estrogens. We related 5 aromatase SNPs (CYP 19 rs2414096, CYP 19 rs936306, CYP...

article

Bone mineral density changes over two years in first-time users of depot medroxyprogesterone acetate

M. Kathleen Clark, MaryFran R. Sowers, Sara Nichols, Barcey Levy

Fertility and Sterility > 2004 > 82 > 6 > 1580-1586

To compare longitudinal changes in bone mineral density (BMD) among first-time depot medroxyprogesterone acetate (DMPA) users to women using no hormonal contraception, and evaluate user characteristics associated with that BMD change. Prospective longitudinal study. Healthy volunteers in an academic research environment. Women, aged 18 to 35, choosing DMPA for contraception (n = 178) and...

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Bone mineral density and fractures among alcohol-dependent women in treatment and in recovery

M. Kathleen Clark, MaryFran R. Sowers, Farideh Dekordi, Sara Nichols

Osteoporosis International > 2003 > 14 > 5 > 396-403

Women are at higher risk for osteoporosis, but most of the literature examining the effect of alcohol abuse on bone mineral density (BMD) has been in men. The aim of this study was to determine differences in BMD and fracture prevalence among women in treatment for alcohol abuse, in recovery and non-alcohol-dependent women. This cross-sectional study was completed at two residential substance abuse...

article

School performance, race, and other correlates of sleep-disordered breathing in children

Ronald D. Chervin, Dave F. Clarke, Jennifer L. Huffman, Erica Szymanski, more

Sleep Medicine > 2003 > 4 > 1 > 21-27

Objectives: Childhood sleep-disordered breathing (SDB) has been associated with poor school performance. Both problems are common among African-American (AA) children, but potential confounders such as low socioeconomic status (SES) and obesity have not been well studied.Methods: Children in second and fifth grades at six urban elementary schools were evaluated by teachers' ratings and year-end reading...

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Search results for: MaryFran R. Sowers

Intra-thoracic fat, cardiometabolic risk factors, and subclinical cardiovascular disease in healthy, recently menopausal women screened for the Kronos Early Estrogen Prevention Study (KEEPS)

Genetic polymorphisms and obesity influence estradiol decline during the menopause

Physical functioning among mid-life women: Associations with trajectory of depressive symptoms

Relating smoking, obesity, insulin resistance, and ovarian biomarker changes to the final menstrual period

Sex steroid metabolism polymorphisms and mammographic density in pre- and early perimenopausal women

Change in adipocytokines and ghrelin with menopause

The Association of Bone Mineral Density with Estrogen Receptor Gene Polymorphisms

CYP1A1 and CYP1B1 Polymorphisms and Their Association with Estradiol and Estrogen Metabolites in Women Who Are Premenopausal and Perimenopausal

Sex Steroid Hormone Pathway Genes and Health-Related Measures in Women of 4 Races/Ethnicities: The Study of Women’s Health Across the Nation (SWAN)

Cognitive Functioning and Sex Steroid Hormone Gene Polymorphisms in Women at Midlife

Introduction

The Association of Genetic Polymorphisms in Sex Hormone Biosynthesis and Action with Insulin Sensitivity and Diabetes Mellitus in Women at Midlife

Menstrual Cycle Markers of Ovarian Aging and Sex Steroid Hormone Genotypes

Sex Steroid Hormone Polymorphisms, High-Density Lipoprotein Cholesterol, and Apolipoprotein A-1 from the Study of Women’s Health Across the Nation (SWAN)

Endogenous Estradiol and Its Association with Estrogen Receptor Gene Polymorphisms

Characterizing Variation in Sex Steroid Hormone Pathway Genes in Women of 4 Races/Ethnicities: The Study of Women’s Health Across the Nation (SWAN)

Aromatase Gene (CYP 19) Polymorphisms and Endogenous Androgen Concentrations in a Multiracial/Multiethnic, Multisite Study of Women at Midlife

Bone mineral density changes over two years in first-time users of depot medroxyprogesterone acetate

Bone mineral density and fractures among alcohol-dependent women in treatment and in recovery

School performance, race, and other correlates of sleep-disordered breathing in children

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