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Adult skeletal muscles in vertebrates are composed of different types of myofibers endowed with distinct metabolic and contraction speed properties. Genesis of this fiber-type heterogeneity during development remains poorly known, at least in mammals. Six1 and Six4 homeoproteins of the Six/sine oculis family are expressed throughout muscle development in mice, and Six1 protein is enriched in the nuclei...
To specify roles of HNF4α in mouse liver development, we have analyzed the ex vivo morphogenetic potential of HNF4α-null embryonic hepatic cells.Using mice with floxed or deficiency alleles of HNF4α, hepatic cells lacking this transcription factor were explanted into primary culture and derived into cell lines.Contrary to behavior in vivo where HNF4α-null liver cells fail to show normal polarity and...
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