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Neuroimaging provides a powerful means to understand the mechanisms that mediate emotional processing in healthy individuals as well as the dysregulation of these processes in post-traumatic stress disorder (PTSD). Reviewed are neuroimaging findings in PTSD, with a focus on studies utilizing symptom provocation, cognitive activation, and functional connectivity. These studies highlight the role of...
Previous research has demonstrated that the rodent medial prefrontal cortex (mPFC) is critical for the expression of unconditioned defense behaviors. The prelimbic (PL) and infralimbic (IL) cortices comprise the majority of the mPFC, but the role of these regions in mediating unconditioned defense behaviors is not well understood. In order to address this, we temporarily inactivated the PL or IL and...
Functional neuroimaging experiments targeting personal recall of emotional events may help elucidate neural substrates underlying posttraumatic stress disorder (PTSD). Studies suggest that limbic and paralimbic function might be altered in PTSD, as compared with trauma-exposed control subjects; however, little is known about functional changes resulting from traumatic experience itself. The present...
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